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Yes, and it has happened before. In the 1972 presidential election, Democratic candidate George McGovern had chosen Misssouri Senator Thomas Eagleton as his running mate for vice-president. During the campaign it was learned that Eagleton had undergone electric shock thereapy and had been hospitalized for mental conditions. McGovern, initially supportive of Eagleton, later agreed that he should not remain as the vice-presidential candidate because of these issues. Eagleton dropped out and McGovern changed his vice-presidentail running mate to R. Sargent Shriver.

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Q: Can a Presidential nominee change his vice presidential running mate before the election?
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