Yes, but it loses its fan speed control.
To do this, you need a power adapter (a computer power supply will work great for this). The Drive will have a molex connector on the back for +12 VDC, ground, ground, +5 VDC. Connect a molex connector to that drive with the proper voltages, and the drive should power on. However, it won't be much good without connecting it to a computer motherboard, or drive controller.
stop cheating!
A Molex power connector is a 4-pin power connector found in most computer power supplies. It is used to provide power to large internal drives like hard drives and CD/DVD drives. They are slowly being replaced by SATA power connectors, which are easier to install can cannot be inserted incorrectly. They should not be confused with a Berg connector which is much smaller and is used to power floppy drives. The molex connector is used for IDE drives
the optical drive will connect to the power supply with a connector called molex connecter it is a 4 prong connector
molex for IDE devices and sata power connector for SATA devices
There are two kinds in common use:Molex - an older standard, but still commonSATA - Serial ATA, a newer standardSee the related links for pictures.
There's different types of connections that lead to a hard disk. you'll have to ellaborate your question.But..... I can tell you what the wires are....There's the ribbon cable. (flat and wide cable that connects to the back of your drive to the motherboard)The Molex plug (white and it has four pins) that powers your hard disks, it leads to the power supply.OR... The SATA power connector (which is black, has 5 wires (red, yellow, 2 black, and one orange) which connect to the back of your hard diskThere's also the SATA data transfer cable, it's a thin (usually red) cable that connects to the motherboard to your hard drive. (it's a thin "L" shaped slot)
Typically, CD-ROMs are connected using a power connector called a Molex Connector. A Molex Connector has four wires, two for power, the other two for grounding. This connector supplies two different voltages to the device it is connected to - 12v and 5v. For more information on Molex Connectors, see the article here: http://en.wikipedia.org/wiki/Molex_connector#Disk_drive_connector_.28AMP_Commercial_MATE-N-LOK.29
If you are refering to the 20 or 24 pin molex connector, this is the motherboard power distribution subsystem from the power supply. If you are refering to the several other small connectors, they have various functions. Front panel indicators and switchs, USB distribution connectors, fans, CD audio, etc.
Connect the front panel molex's to every available connector (3-pin molex connector) Or get a new one. I am experiencing the same now.
The tool designed specifically to test DC current from a Molex connector is called a Power Supply Tester.
Molex Connectors are used in Power Supplies for powering up the devices. There are different types of Molex Connectors on Power Supply for. eg. 20 or 24 Pin Power Connector\ 4 Pin IDE device \ Sata Device Connector.Mini Molex refers to connector powering Floppy Disk Drives or AGP Cards on Computer System.