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Yes, Cortisone can have side effects,sometimes severe. Corticosteroids are a class of medications that are related to cortisone. Medications of this class reduce inflammation. They are used to reduce inflammation caused by a variety of diseases. Cortisone is one type of corticosteroid.

Side effects include thinning of the skin, easy bruising, weight gain, puffiness of the face, elevation of blood pressure, cataract formation, thinning of the bones(osteoporosis) and a rare but serious damage to the bones of the large joints (avascular necrosis). Tendon weakness and rupture have also been reported.

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