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Yes, defective genes can lead to repeated loss of pregnancy. Everybody has 2 copies of chromosomes in their body they get one from their mother and one from their father. When 2 defective copies come in the child depending on the severity of defect it survives. In case of an unacceptable defect it aborts usually known as spontaneous abortion. This is natures way of getting rid of unwanted combination of defect.

Mother can get ultrasound done routinely. First and second trimester screening also identifies genetic defect if present. More genetic defects can be identified by Newborn Screening for congenital metabolic errors for more than 100 IEM (Inborn errors of metabolism).

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