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Quite obviously yes. If you don't use it you lose it simple as that.

NASA does experiments with people lying in bed for up to 3 months at a time, as a way to simulate the effect of weightlessness on astronauts. They say that the effects of 3 months in bed "aren't pretty", and the participants end up with muscle and even bone density loss.

The body, of course, is merely adapting - if you never move anyway, you don't need all this muscle and bone, and the body gets rid of it for you.

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Q: Can inactivity cause muscle loss or weakness?
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