the activity of the enzyme UDP-glucuronyl transferase is low in the newborns.so UDP- glucuronic acid for conjugation is limited. this leads to high level of unconjugated bilirubin (beyond 25mg/dl) .it may cross the blood brain barrier resulting in hyperbilirubinemic toxic encephalopathy or kernicterus .
prevention aspects:
the drug phenobarbital is used, as it induce bilirubin metabolising enzymes in liver.
in some neonates blood transfusion may be necessaryto prevent brain damage.
phototherapy is continuously carried out till the serum bilirubin becomes normal.
phototheraphy deals with the exposure of the jaundiced neonates to blue light as bilirubin absorbs the blue light and get converted to non toxic lumirubin and get excreted.
Vaccines for hepatitis A, hepatitis B, and yellow fever can prevent jaundice due to viral infection.
Jaundice
Infant jaundice can be fatal if untreated. Most infants recover.
John Dice discovered Jaundice.
what substance is responsible for the jaundice
Jaundice is spread by impure water.
Ernest Hemingway did have jaundice at one point of his life. He was hospitalized in Milan because of bad jaundice.
jaundice
Jellinek's disease jaundice
yes, obstructive jaundice.
Yes, it is possible to have jaundice and not know. However, these are doing the very early stages of jaundice.
Jaundice is a descriptive term for yellow skin. Your skin won't turn yellow from kissing someone. If the cause of their jaundice is an infectious diease, you may contract it from kissing. The viral hepatitis infections are not spread by kissing.