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Yes it may happen, if the mating between the man and the women is regular. During mating, when a man's penis is penetrating a women's vagina, her fluids also contact his penis, and his body may get allergic to it. Condoms can be used to prevent it. However, it is possible to be allergic to condoms as well - latex and/or lambskin.

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Q: Can man be allergic to a woman's vaginal secretions?
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