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Only when such patients are properly monitored by doctors. The possible problems with female hormones include blood clots, stroke, liver disease, elevated prolactin level, a type of benign brain tumor, and possibly even cancer. So the doctors would want to check regularly for liver function, clotting times, and prolactin levels, among other things. The patients would be advised not to smoke.

While the FDA is silent on this, and no specific studies have been done, anecdotal evidence and common sense seems to suggest that female hormones are safer to take when oral administration is avoided. The logic for that pertains to the way the liver works. If you take estrogen orally, it passes the liver twice. Also, the liver may have receptors to cause blood clots. That is why most non-human mammals eat afterbirth. The hormones cause the liver to make more clotting factors to slow the bleeding from giving birth.

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10y ago
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14y ago

Only under doctor's supervision since there are side effects. This is usually done when a man transforms into a woman.

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Q: Can men take female hormones safely?
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