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You can check all known interactions by looking at the related link below. Simply type in the drugs you wish to find and select the correct drug from the drop down menu. All known interactions will then appear.

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* methadone * Wellbutrin (buPROPion) ---- 1 Interaction found:

# methadone and Wellbutrin (buPROPion) (Major Drug-Drug) SERIOUS PROBLEM: The use of bupropion is associated with a dose-related risk of seizures. The estimated incidence of seizures is approximately 0.1% at dosages up to 300 mg/day and 0.4% at dosages between 300 to 450 mg/day, but increases almost tenfold between 450 mg and 600 mg/day. The risk may also be increased during coadministration with selective serotonin reuptake inhibitors (SSRI antidepressants or anorectics), monoamine oxidase inhibitors, neuroleptic agents, central nervous system stimulants, opioids, tricyclic antidepressants, other tricyclic compounds (e.g., cyclobenzaprine, phenothiazines), systemic steroids, and/or any substance that can reduce the seizure threshold (e.g., carbapenems, cholinergic agents, fluoroquinolones, interferons, chloroquine, mefloquine, lindane, theophylline). These agents are often individually epileptogenic and may have additive effects when combined.

POSSIBLE SOLUTION: Extreme caution is advised if bupropion is administered with any substance that can reduce the seizure threshold, particularly in the elderly and in patients with a history of seizures or other risk factors for seizures (e.g., head trauma; brain tumor; severe hepatic cirrhosis; metabolic disorders; CNS infections; excessive use of alcohol or sedatives; addiction to opiates, cocaine, or stimulants; Diabetes treated with oral hypoglycemic agents or insulin). Bupropion as well as concomitant medications should be initiated at the lower end of the dose range and titrated gradually if feasible. The total dose of bupropion should generally not exceed 450 mg/day (or 150 mg every other day in patients with severe hepatic cirrhosis). Bupropion should be discontinued and not restarted in patients who experience a seizure during treatment.

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14y ago
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12y ago

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Yes, it can. There is no known interaction between the two. However, you should ask your doctor, just in case. If you wish to check for yourself, see the Related Link below for the drugs.com page.

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If your doctor is prescribing both medicines and is keeping a close eye on you, then it is OK. If you have one prescription from one doctor and the other from a different doctor, then no. You need to tell both doctors everything you take so they can decide which dose and what medicine you need.

Both of these medicines are in the most addictive category of drugs, which means they are the most dangerous.

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11y ago

I have heard it does help, but again, I don't know why you would want to take another seriously addictive substance to get off another. Makes no sense to me. ALL people are going to feel some discomfort when getting off narcotics. The best way to avoid major withdrawal symptoms is to taper off of it very slowly. Therapy is also a big part of recovery and staying clean in the long term if you feel it will be a problem.

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