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It may if you don't hydrate yourself enough. I had a major nose bleed at the gym two days ago. My buddy and I were hammering reps like we had prior to starting creatine and 48 hours prior, and my nose started bleeding out of nowhere. I have no history of nose bleeds and haven't had one since I was in 7th grade (29 yrs old now). Also, I was coughing blood where it was going down the back of my throat. I'm a nurse and had symptomatic hypertension (headache, dizziness, and cranial pressure). My blood pressure 40 min after the bleed was 138/74. Normally it is in the lower 120's systolic. Creatine attracts water into your cells so you need more fluid to compensate your extracellular fluid plasma. It would be reasonable that this could cause hypertension with dehydration. Be careful with this supplement. I probably should have drank way more water than I had prior to arriving at the gym, but still with 1.5 hours of reps you can easily get dehydrated. Get a water bottle and be careful.

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Q: Can the use of Creatine cause nose bleeds?
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