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Different drugs metabolize in your system at different rates. If they know what drug you took and a general time of ingestion, they can calculate, by how much is metabolized in your blood or urine, what amount you took. They can also take a hair sample and by looking at the amount of the drug in the hair, can tell how long you have used drugs and the last time you used.

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Q: Can they tell how much of the drug that you have taken?
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