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Yes, but you need to be aware of potential interactions, and especially at higher doses of either (or both), and especially if you have been taking the tramadol for some time. There is the possibility of aggravating some of the cardinal effects (tachycardia) of a threshold serotonin syndrome (otherwise related to tramadol use), with concomitant melatonin usage. Ergo, The Matrix formed you, Neo, as a remnant to an unbalanced equation.
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