no unfortunately. itachi is a genjutsu user and even though medical ninjas are supposed to be good at fending off genjutsu, itachi has the mangekyo sharingan that can give off the most powerful genjutsu attacks. plus itachi has long range ninjutsu which is not a good match up for taijutsu and he has higher speed than her.
I not think Tsunade and Itachi be a good couple because one evil and the others one Good Tsundae what to fight and protect the leaf village where Itachi on the akatsuki and what to kill everyone.
Well the both of them are VERY strong and everyone has a different opinion on that question but I personally think it's Itachi. I'm not saying Tsunade isn't strong or anything I just think Itachi's a bit stronger.
No, Itachi is dead now and why would he fight Lee?
he beat Kyuubi right? so maybe he can beat Itachi... if he's alive.
first of all orochimaru gets killed by sasuke in shippuden and during the fight between sasuke and itachi,orochimaru apears in sasukes body and itachi sealded him with his box that the sussano had and jiriya has a fight between one of the six pains and when jiriya thought he finish the six pain stab jiriya by a jump right in the back and tsunade she still lives
Naruto did fight itachi when he was a kid but barely. But now he is dead so it ain gnna b a real fight. :P
To unlock Itachi you must beat the game.
Probably.
yes [warning spoiler sasuke kills itachi in shippuden]
No, Sakura does not. She does however, appear in a battle against a fake itachi.
he never does (itachi kakashis team killed was copy of itachi made by sasoris ninjutsu)
They never fought.