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Noone can really tell you unless they are a licensed pharmacist or psychiatrist etc. but I highly doubt there is any reaction considering trazodone consists of potentiating serotonin and norepinephrine, but xanax depressed subcortical levels of cns, so unless you take high doses I think it will be perfectly fine.

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Q: Can xanax and trazadone be taken together for insomnia?
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