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If you unplug an IDE drive, you run the risk of burning out that IDE channel that it is plugged into. I have unplugged them several times with no ill effects but I've probably just been lucky. SATA drives can be hot-swapped (you eject them in Windows as you would a thumb drive) and external hard drives plugged into a USB port can also be ejected. If you have a RAID, you can also hot-swap.

Also be aware of static electricity. A static charge that you cannot even feel can still burn out motherboard circuitry when changing hard drives, or doing anything else.

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Q: Can you blow a motherboard by unpluging hardrive and plugging in a different one?
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