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You can clean the cage, but leave the nest undisturbed. Once the babies are one week to 10 days old, you can clean their nest as well. Try to clean the cage during the day when your mice are asleep. Simply leave them where they are, and hopefully they'll sleep right through the whole thing. Preferably, you knew that your mouse was expecting, and you cleaned out the cage in the last few days of her pregnancy. If not and you feel that you must clean the whole cage, remove the babies with some of their bedding, and if they have a house, place it back on top of them. Do the best you can to make sure that mom doesn't feel threatened. Once the cage is clean, put the babies back in with a little bit of the bedding left. Make sure that you place the nest in the same place where it had been before, and that when you're done, you give them peace and quiet.
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