Yes prepare your wallet
Buffalo, NY is about an hour and a half drive from Jamestown. Id say a little over 74 Miles.
According to mapquest.com, it will take 21 1/2 hours to drive the 1394.7 miles from Buffalo NY to Miami FL
Buffalo, NY to Hilton Head Island, SC is about 900 road miles.
I takes about 1 hour and 54 minutes to drive from Buffalo,NY to Toronto,Ontario,Canada.
The distance between Buffalo, NY to Hilton Head, SC is about 912 miles which is about 15 hours and 8 minutes drive.
Assuming you meant Buffalo, NY to Manchester, NY. They are about 90 miles apart on the I-90E - 1.5 hours.
Basically 3 hrs and 40 minutes
Buffalo Bills One Bills Drive Orchard Park, NY 14127-2296 (716) 648-1800
1890 kilometers (1174 miles).
Drive: about 2 hours
The trip from Oakville, Ontario to Buffalo, NY takes about 2 hours; with a distance of 76.38 miles according to MapQuest.
Check Mapquest.com