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Sumatriptan is a commonly prescribed migraine medication. The most common active ingredient in medications for migraines is caffeine. However this medication does not contain caffeine. In conjunction with Acetaminophen (Tylenol) it should be fine.

However do not consume the maximum of 4000mg of Acetaminophen in one day while taking Sumatriptan. It is advisable to only take around 2000mg (approximately 4 tablets of extra strength Tylenol) in one day while taking a prescribed migraine medication. This is due to the toxicity that can be caused in the hepatic system (liver, kidneys, and bladder).

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13y ago
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14y ago

I would not take them at the same time for one reason. When you have a migraine, you're going to have nausea. Take the Imitrex first, at the onset of the headache. Once you have the migraine under control, you can take your sedative if you need to.

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Q: Can you mix Ambien with sumatriptan?
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How long does sumatriptan stay in system?

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no