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Absolutely - the two are often prescribed together as part of an opiate patient's pain management therapy, with the Fentanyl Patch being the primary pain med, and the Oxycodone (usually Percocet, but it can be just Oxycodone or Oxy ER) as the breakthrough medication.

Initial patch dose estimates are always skewed toward the low end, and as a result, the initial dose usually isn't enough. That's why Percocet (oxycodone/tylenol combination) is usually prescribed at the outset. After the patch dose is nailed down. Percocet or Oxycodone is still prescribed as the breakthrough med for when the patient's activity raises pain levels to the point where it's exceeding the patch pain relief ability.

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11y ago
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15y ago

Yes, it is done everyday. Pain patients may have the Duragesic patch and also have emergency oxycodone tablets up to 30mg. However, these people have a largely developed tolerance to the opiate drugs. I would not recommend doing it unless you have a very large tolerance. Hope this answers your question. Stay safe!

-Patrick (Future Pharmacological tech)

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6y ago

No, since they act through the same mechanism. It may lead to adverse reactions

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