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There are no direct physical dangers from mixing Zoloft and Ecstasy (MDMA). Zoloft (or to use its chemical name, Sertraline) is an SSRI (selective serotonin reuptake inhibitors), the same class of anti-depressants as Prozac (Flouxetine), Celexa(Citalopram Hydrobromide), Luvox (Fluvoxamine), and Paxil (Paroxetine). These chemicals will actually reduce or even completely eliminate the effects of Ecstasy when the two are taken together. Also Celexa in particular is sometimes used to treat cocaine-dependency and may reduce cocaine effects and craving.

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