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Yes. Pain Mangement doctor's routinely combine Hydrocodone and Flexeril(Cyclobenzaprine) for a better pain relief. Other drugs mixed with hydrocodone to increase its painkilling ability are: Vistaril, Flexeril, Lyrica, Cymbalt and Norflex (the most effective with least effects is Norflex)

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14y ago
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15y ago

my doctor prescribed both to me and they seem to be working fine. Ask your doctor if its okay for you.

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Q: Can you mix flexiril and hydrocodone?
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