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The short answer is no. The longer answer is, you may be able to get a .25 cartridge into a .22 caliber gun, but it will likely jam and be very difficult to get out, and if it fires, it will probably damage the gun and possible the shooter. The .25 has a larger diameter than the .22.

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15y ago
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Q: Can you put a 25 caliber in a 22 caliber handgun?
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