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Depends. If you mean the Ruger Mini-14 or Ranch Rifle, yes, you can. It is chambered for .223 and 5.56x45 ammo. If you read the owner's manual (available on the Ruger website) it will tell you that on page 13. The Target Model is ONLY for .223. Of course, the 6.8mm and the Mini-30 use different ammo entirely.

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Q: Can you shoot 5.56 mm ammo in Ruger?
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