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Absolutely, just be aware that the +P designation stands for higher pressures. I have thousands of +P rounds through a few of my M&P's without issue. Accelerated wear is the only concern, and even then I would say the average person won't approach the amount of rounds it takes to cause any issues.

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Q: Can you shoot plus p ammunition in a smith and Wesson m and p 45 caliber semi auto?
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