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Pregnancy is unlikely, but not impossible while on Depo. However, all people are different as well as their genetic make-up, so some individuals do spot while others do not. I've been on it for 5 years, and usually after surgery I do spot. But in the first year, I bleeding 4 months after I received the injection and had to return to the doctor's office to obtain an estrogen (female hormone) injection and the bleeding diminished.

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16y ago

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