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Yes - Singulair has primarily been used as an Asthma drug in the past, and is only now being marketed as an Allergy drug as it works differently than traditional antihistamines. It takes time to build up in your system to be effective. Benadryl is a fast-acting antihistamine used for dealing with allergic reactions more quickly, where Singulair is a preventative medication.

I've used Singulair for Asthma since it became available, and along with Zyrtec, it keeps my Asthma symptoms to a minimum. However, occasionally I'll need the fast response of Benadryl (properly used it can also help with anaphylactic reactions) when allergic conditions warrant it. Keep in mind though that everyone is different, so check with your doctor first to see if it's okay for YOU to do it. Just because I and others can doesn't necessarily mean it's okay for you.

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Q: Can you take Benadryl after taking Singular?
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