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It depends on which other medications you are on. Elavil (amitriptyline) is as effective as Paxil (paroxetine), if dosed properly. However, Elavil is far more anti-cholinergic, meaning that it causes drying of the mucus membranes - and, therefore, constipation, urinary retention, dry skin, dry eyes, and even "dry brain" (which is a medical colloquialism indicating for poor concentration and short-term memory, and even confusion) could occur - especially when any dehydration might occur.

Elavil is also more cardiotoxic, and has far more interactions with other drugs and medications, than Paxil (or other SSRI antidepressants).

Check with your prescribing physician before making this very significant kind of change in your medication regimen.

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Q: Can you take Elavil in place of Paxil?
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