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Yes you can, but like any drug you need to be aware of its effects on you, and how much more of a depressant effect it will have on you in addition to what you experience with Fentanyl. I've used Fiorinal w/ Codeine (Fiorinal uses aspirin rather than Tylenol, like Fioricet does) for over 20 years for Migraines, and have used 100mcg Fentanyl patches for about 9 years. The Butalbital in the Fiorinal is the only thing anymore that still makes me a bit drowsy - there are few things that can anymore with the amount of opiates I've had to take for so many years.

However, I'm highly tolerant to opiates and most depressants - it takes quite a bit to knock out most people who use Fentanyl on a regular basis, as Fentanyl is itself is used an an anesthetic normally. I'm also not a small person by any means - I'm 6' and 250 lbs.

Like with any drug you mix, it's always good to get your doctor's advice, since there may be other mitigating factors in your health that might preclude mixing the two. But as a general rule, there's no problem with using the two together, as they work a bit differently and on different areas of the body.

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14y ago
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15y ago

yes

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Q: Can you take Fioricet and Fentanyl?
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