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These drugs are not known to interact. However, Levothyroxine can cause some people to feel flushed or jittery after taking it. ibuprofen increases gastric acidity and can cause heartburn symptoms or gastric ulcers in time. Both of those effects at the same time sound uncomfortable. Also, it is almost never a bad idea to space out drugs throughout the day to avoid them mixing within your stomach. But, really, there should be no problem, especially if you've taken these drugs independently with no issues.

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Q: Can you take Levi thyroxin and ibuprofen together?
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