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Generally, no. Most versions of NyQuil contain dextromethorphan which, when mixed with an SSRI such as Prozac, may cause seratonin syndrome, which is rare but potentially fatal. Symptoms include irritability, confusion, vomiting, etc. Some versions of NyQuil do not include this ingredient and may be safe to take. Check all the ingredients listed and talk to your doctor or pharmacist first!

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Q: Can you take NyQuil while on Prozac?
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