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NyQuil already contains doxylamine, which is almost exactly like Benadryl (diphenhydramine), so it wouldn't be a good idea to take them together since that would be a "duplication of therapy". If the NyQuil isn't keeping your congestion down, you could probably take 25 mg of Benadryl (diphenhydramine) and be OK.

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12y ago
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11y ago

I've mixed NyQuil (when sick, not for recreational use) and unisome before (unisome is like ambien or lunesta) as well as Nyquil and the prescription sleeping med Trazidone. As long as you take them at the right dosages, and check up to make sure its not a specifically bad chemical reaction, you should be fine. Just be careful that the Nyquil doesn't already have some of what is in the sleeping medicine, (example: acetaminophen of about 600mg is common in most nyquil and sleep aid products, make sure you don't take anything else with acetaminophen... which is not in sleep aids but simply as an example) You should be fine. :)

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15y ago

You can check all known interactions of drugs yourself with the website http://www.drugs.com/drug_interactions.php. Simply type in the drugs you wish to find and select the correct drug from the dropdown menu. All known interactions will then appear.

---- Interactions searched:

* acetaminophen (Ingredient of Nyquil Cold & Flu) * benzonatate * dextromethorphan (Ingredient of Nyquil Cold & Flu) * doxylamine (Ingredient of Nyquil Cold & Flu) * hydrocodone ---- 1 Interaction found:

# hydrocodone and doxylamine (Ingredient of Nyquil Cold & Flu) (Moderate Drug-Drug) PROBLEM: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.

POSSIBLE SOLUTION: During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

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12y ago

im debating the same thine right now, i took benadryl like 8 hours ago, but i want to take NyQuil now.

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Q: Can you take NyQuil with benzonatate?
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