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Q: Can you take Z-PAC with Valium and benadryl?
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Can you take Valium with Benadryl?

We have mixed small(ish) doses of Valium with benadryl in order to get a deeper sleep on long flights. Haven't had any problems. The benadryl seems to amplify the effect and actually cause sleepiness, while Valium on its own just has a relaxing (but not necessarily sleeping) effect. Just be careful not to take too much benadryl or you will be REALLY TIRED for a LONG TIME. And no, I don't mean death. : ) Just tired. *Doses have been 10-20 mg of Valium and a swig of children's liquid benadryl* And please note that WE ARE NOT DOCTORS so please CONSULT YOUR PHYSICIAN if you have any questions!!!!


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Promathazine and Diphenhydramine (Benadryl) are antihistamines. Both have remarkable sedative action. They should not be taken together and with Valium also. All the three drugs will sedate the patient heavily.


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