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Because they both contain antihistamines, they will cause a reaction. Tylenol PM has the same antihistamine as Benadryl and it is not recommended that you take Zyrtec and Benadryl at the same time. Contact you doctor to verify if you can take your Zyertec in the morning (as usually prescribed) and the Tylenol in the evening. Zertec is a long acting antihistamine and should be out of your system before you go to bed. The Tylenol PM is a short acting antihistamine and would be out your system before your morning dosage.

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Q: Can you take Zyrtec and Tylenol PM together?
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