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Zyrtec (cetirizine) and Vyvanse (lisdexamfetamine) have no known major drug to drug interactions, and can be taken safely together. However this combination may cause a increased sedating effect, so until you know how severe this effect is; you shouldn't operate a vehicle/heavy machinery because you could fall asleep at the wheel.

Of course I must insist that you clear this answer with a physician and/or a primary healthcare provider.

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14y ago
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14y ago

Vyvanse is essentially a form of extended release amphetamine (think Adderall) but with a few structural changes to prevent abuse (it is inactive if insnufflated or injected). Since Adderall can be taken with Strattera, it follows that Vyvanse should also be able to be taken with Strattera. Though it should be noted that when Adderall and Strattera are combined, the dosage of Adderall should be decreased fairly significantly. You'll commonly see combinations of around 80mg Strattera with 10mg Adderall, for example. Since Vyvanse tends to have a comparably higher load of amphetamine than Adderall XR, I would strongly recommend consulting a physician before combining them.


The combination of Strattera and Vyvanse is considered to be not dangerous. But when they are used together, their recommended dosages must be decreased. Only your doctor can determine them. If not, their combined action may worsen possible side effects of them both. To avoid possible risks, they usually recommend to make choice in favor of the drug you tolerate better rather than combine them.

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13y ago

No, it is not recommended. Wellbutrin (bupropion) and Vyvanse (lisdexamfetamine) are dangerous if taken together because this combination has been known to cause seizures (which can be fatal if not controlled).

THIS IS NOT TRUE. I have been on these two medications for two years, and not have any problems. Maybe leave these questions to be answered by health care professionals. If you are concerned about mixing two meds, call a pharmacy, they have the training to give you an answer right away, and an answer you can trust.

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14y ago

There are no known drug to drug interactions between these two medications, making them safe to take together. Make sure to contact you primary care provider prior to taking these two medications to ensure that it is safe.

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15y ago

No, please take my advice and not do this , it is very dangerous,

and can seriously injure or kill you.

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12y ago

Adderall is amphetamine, Vyvanse is lisdexamfetamine, which your body turns into amphetamine, so it'd be like taking a double dose

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Q: Can you take Adderall and vyvance?
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