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I have and it did not affect me at all. I needed the energy regardless of my mood disorder or whatever you want to call it. It does say to consult a doctor if you're on medications before taking 5 hr energy but I did it anyway a few times, and i was fine. Drink lots of water to keep your body temperature moderate and you won't get flush and you will maintain a peaceful mind.

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Q: Can you take a 5 hour energy shot while taking zoloft?
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