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Generally, I would not advise it because of the double sedative effect that could occur. Benadryl which is OTC (over the counter) is commonly used as an anti-histamine. Ambien (a prescription) is used specifically for bed-time rest.

However, they can be used together. Senior citizens, people with respiratory issues and the physically handicapped should be monitored from time to time while using these products, especially simultaneously.

- i definitely wouldn't. A friend of mine passed away from it

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14y ago
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Wiki User

9y ago

Questions like this should only be directed at qualified medical personnel whose credentials can be easily verified - not a site like this, where anyone can answer with no assurance that the answers are in any way accurate.

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16y ago

Yes they are safe to take together, but be very careful because if you do take them together, you will probably get very tired. Definitely do not drive.

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15y ago

It's safer for you to call your pharmacist or doctor and ask them because they are better qualified.

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13y ago

Due to concerns of possible oversedation, this issue should be discussed with your prescribing physician.

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Q: Can you take ambien and Xanax with Benadryl?
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