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Only if you stay within the recommended dosage. They both contain diphenhydramine. Excedrin PM you can not exceed 2 per night(or in a day) and if you were to take benadryl with it you would be exceeding the recommended dosage. If you took 1 of each in a day you would be OK. I was taking 2 Excedrin PM per day along with 2-3 Benadryl and my eyes became extremely dry and it was hard getting through the day. Once medications stopped eyes slowly started to get better. This is only a minor complication though. There are serious side effects if the dosage is not followe.

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Alena Robel

Lvl 10
2y ago

What else can I help you with?