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These medications together have a moderate drug interaction. When taken together, they will depress the Central Nervous System along with your breathing. Be very careful while taking these medications together and please be sure to ask your doctor as you may have some health issues that could effect this interaction even more.

Dr. Jacob M. Deese, MD

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12y ago
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12y ago

yes hydroxyzine increases the effects of the percocet and reduces side effects. but only if instructed by your doctor

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9y ago

Yes

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