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You can take opioids such as morphine and diamorphine with a low dose of dimenhydrinate (Gravol), but dimenhydrinate's active metabolite, diphenhydramine, is a CNS depressant; therefore, the combination of opioids and H1 receptor antagonists -being 1st generation antihistamines and other anticholinergic drugs- can definately increase the respiratory depression associated with opioid analgesics.

Methadone and dimenhydrinate is particularily more dangerous than most opioid combinations, this is because of the cumulative effect that methadone is notorious for, as well as methadone's high rate of respiratory depression.

Now, with buprenorphine, the active component in Suboxone, your respiratory depression rate is significantly less than with most other opioids because of the ceiling effect.

In light of these factors, my answer would be that it would be relatively safe to take a small dosage of dimenhydrinate with Suboxone.

The dosage taken would be relative to your dose of Suboxone.

Combining sedative/depressant drugs is never necessarily safe, however, if you know how your body reacts to the drugs in question, and you are sure that you are taking doses within your safety-range, then buprenorphine and dimenhydrinate can be a very safe combination despite their synergy of effects.

An example of a safe dosage in my scenario is as follows, I currently take 8mg Suboxone SL/PO daily and often safely take 25mg-50mg dimenhydrinate with multiple doses of GABAergic herbals through the day. Sometimes these doses taken with a few glasses of wine before bed.

Remember that Suboxone is very potent, 8mg being equal to a daily dose of 120mg morphine. Base your judgement on knowledge of the chemicals as well as your own body and always be safe.

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Q: Can you take gravol and suboxone at same time?
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