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(I am not a doctor) I have been taking 300mgs of Lamictal once a day for 10 years due to a seizure disorder and in that time I have taken Benadryl for seasonal Allergies. I noticed no adverse effects. It may be only subjective, but it is possible that Lamictal could reduce the effectiveness of Benadryl, but I never noticed any other kind of contraindication. But as with any drug you are unsure about, always consider what other medications you are currently prescribed.
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