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In my case, yes. I have been on both for the past 6 months. The Vivelle patch has been effective at controlling all my physical symptoms of menopause (hot flashes, cold spells, muscle/joint aches & pains, etc.) and the Prozac (20mg/day for me) has been extremely effective for management of my depression. The only drawbacks have been: weight gain (15 pounds over the 6 months) due to cravings for sugar, carbs, and a general disinterest in "healthy foods" like vegetables (representing a real change in my attitude towards food). I also find myself being rather impulsive with my spending - an odd thing, to be sure, but again, it's a shift in my attitude towards spending that is very new for me.
My gyn prescribed both for me when the patch was not enough to control my depression, which was due to a decrease in hormones. Good luck with your health.
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