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There is a scale that rates drug interactions---Mild, Moderate, and Major. Taking methocarbamol (trade name Robaxin) with the antidepressant Lexapro is rated MODERATE on many internet sites, and generally not recommended. I am answering this question because just 48 hours ago, I took that very combination after the urgent care center doctor prescribed it and the pharmacy dispensed it with no warning to me about possible interaction side effects. I experienced extreme agitation, hyperventilation, uncontrollable sobbing and then shallow breathing. Thankfully my son is a certified pharmacy technician and quickly looked up the information online as my husband tried to calm me down. So, yes you can take these drugs together, but consult with your pharmacist and physician first!

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11y ago
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Q: Can you take methocarbamol while taking Lexapro?
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