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Methotrexate is not known to have interactions with Tramadol, but they can both strain the liver and kidneys. Methotrexate can cause such a heavy liver strain, that it is standard to have to get a monthly blood test to monitor function. It is important to ask your doctor how your tests are going, and if this option is good for you in specific.

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7y ago
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6y ago

As a disclaimer, any questions about drug interactions your may have should be directed to a physician or pharmacist for more information. Also, by thyroxine, I'm taking the liberty of assuming you meant levothyroxine, since no such drug exists.

Regarding this combination, Zoloft and Tramadol are flagging as having the potential for a major interaction and before taking this combination, you should immediately involve a pharmacist. There is a potential for a rare but serious condition called serotonin syndrome, especially dependent on your current dosage. This condition can cause confusion, hallucinations, extreme changes in blood pressure and heart rate, and other severe side effects.

There were no other interactions flagged between the other medications.

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12y ago

Yes , but leave at least two hours between the dosages to allow good absorption of the thyroxine

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Q: Can you take tramadol methotrexate zoloft and thyroxine together?
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