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Yes, combining oxycodone and aleve cause no adverse reactions. However, unless you are taking oxycontin, it is more than likely you are taking a preparation of oxycodone and a drug similar to aleve such as acetaminophen (tylenol) or ibuprofen (advil). Your prescription bottle will be labeled with any mixer in the preparation. If it has a mixer in it aleve would probably do little to further relieve pain, and taking aleve on top of a mixer could potentially be hard on your liver. unless you are absolutely positive there is no mixer, I would not suggest taking aleve with oxycodone.

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17y ago

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