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You can if you do not exceed the maximum dose of Tylenol taken at a time (1000mg) and during the day (4000mg). Tylenol 3 contains 300mg of acetaminophen. Tylenol Extra Strength contains 500mg of acetaminophen, Tylenol 8 Hour contains 650mg of acetaminophen. So, you have to count not to overdose.

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Q: Can you take regular Tylenol with Tylenol 3?
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