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Top Round is a much better cut and very lean. Its delicious broiled to medium rare & sliced across the grain...a traditional "London Broil". On the other hand, recipes for long & slow cooking usually love the chuck. You could substitute and it would be delicious, rather like using a cup of cream when regular old milk would do.

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Q: Can you use London broil top round roast when recipe calls for chuck-eye roast?
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