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There are no drug interactions between Tylenol and Benadryl (in fact Tylenol PM is the same thing) but you should always use care administering any OTC medication to young children.

Consult the labels on the packaging to learn manufacturer's recommendations and the recommended dosage.

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15y ago
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10y ago

Benadryl and Tylenol are different classes of drugs so if given in proper amounts for the child's age the simple answer is yes. However, some children's tylenol contains benadrl so you would be increasing the amount if given with Benadryl by itself. Consult your pediatrician for specific dosing instructions (the nurses can usually answer these sort of questions over the phone).

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11y ago

If the doctor says so. It's important to seek health advice from your child's doctor, not people on line. You may want to give one and 4 hours later give the other one.

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12y ago

Yes, the dosage range for children is 1mg per kilogram of body weight. Take the child's weight and divide it by 2.2 and that's how many milligrams of Benadryl they can take safely.

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Q: Can your five year old take Motrin and benadryl?
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