catecholamines
which causes:
Increased BP- can lead to stroke
Cardiac Acceleration- leads to dysrhythmias (impaired electrical activity)
Vasoconstriction- leads to Stroke or MI
CNS stimulation- leads to seizures
Anticholinergics- leads to gastric ulcers
Dopamine.
sympathetic agonist
blocks the reuptake of serotonin.
Cocaine (benzoylmethyl ecgonine) is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant.[5] The name comes from "coca" in addition to the alkaloid suffix -ine, forming cocaine. It is both a stimulant of the central nervous system and an appetite suppressant. Specifically, it is a dopamine reuptake inhibitor, a norepinephrine reuptake inhibitor and a serotonin reuptake inhibitor, which mediates functionality of such as an exogenous DAT ligand. Because of the way it affects the mesolimbic reward pathway, cocaine is addictive.
an antagonist
Cocaine is a dopamine reuptake inhibitor, causing a build-up of dopamine in the brain. That build-up is associated with the euphoric sensation often referred to as a "high."
Sertriline (Zoloft) Selectively blocks reuptake of serotonin, enhancing serotonergic function. It is an antidepressant.
It is a norepinephrine reuptake inhibitor. Norepineprhine is a stimulating neurotransmitter. It makes you feel up, energetic, and hyperactive. It also increases your heart rate and blood pressure. When norepinephrine is released from nerve cells in the synapse to send a signal on to the next nerve cell, there is a reuptake pump that removes the norepinephrine to cut the signal off. This keeps the pathway from firing to much or too long and preserves the norepinephrine for future use. Cocaine blocks the reuptake system and makes the stimulating stronger and last longer. However it that means that you also deplete your supply of norepinephrine and "crash". This makes you feel tired. So you keep wanting more cocaine to get back to that good (high) feeling, but because you have used up the norepinephrine you never quite reach it. That makes cocaine very addictive.
blocking the dopamine or monoamine reuptake into the presynaptic axon ending
Pure Cocaine (benzoylmethylecgonine) does not contain any other ingredients. Cocaine asts as a Dopamine Reuptake Inhibitor, Dopamine is an organic compound used to regulate hunger. Cocaine stimulates Dopamine transmitters in your brain, which,among other things, gives it appetite suppressing effects.
Cocaine and crack cocaine are psychostimulants that affect neurons containing dopamine in the areas of the brain known as the limbic and frontal cortex. When cocaine is used, it generates a feeling of confidence and power. However, when large amounts are taken, people "crash" and suffer from physical and emotional exhaustion as well as depression.
blocks the reabsorption of dopamine
It is neither of the above mentioned compound types. It is a serotonin agonist and reuptake inhibitor. It's also what is called a tri-cyclic antidepressant.