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Cocaine blocks the removal of Dopamine from the synaptic cleft, causing the existing Dopamine to bind again and again, overstimulating the cell. At first the cell just fritzes out- producing the high. But then, to counteract the extra stimulus, the body starts to remove Dopamine receptors. That's why it takes an ever increasing amount of cocaine (or meth or whatever stimulant you choose) to produce a similar high.

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Q: How does cocaine affect the transmission of nerve impulses?
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