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(Asker) Muscle cells have a lot of mitochondria in them. Is it theoretically possible that mitochondrial toxicity, which can sometimes be caused by several known Antiretroviral Therapy drugs, could lead to Wasting (loss of 10% body mass)? It would seem like the deterioration of Mitochondria would lead to the death of muscle cells, and in turn deteriorating the muscles, then in turn cause the loss of body mass. I know that muscle isn't the only type of mass in the body, but is this possible in terms of losing muscle mass?

I haven't been able to find any research documents linking the two, so I was just making hypothetical possibilities. It seems like it could at least be possible, if not probable. What do you think?

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14y ago

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